72 years old male patient complained of symptoms of Myocardial Infarction 7 years ago, today he is complaining of Skin tightening over the hands symmetrically Proximal to distal, difficulty swallowing and paraesthesia in the hands only. There is no kidney failure , no lung affection, and no other system affected
.
Main etiology of this case:
Chroninc Systemic Autoimmune Disease of unknown origin charaterazied by above symptoms. Noted: Immunity protect our body against pathogens but in this patient , pathogens let the immunity unable to recognize their body connective tissue and producing Auto-antibody that attract our connective tissue instead of pathogens ; suppose to be attracted pathogens. Why do our Antibody attract our own tissue in this case ? No one knows it yet :)
Mechanism of cause: shown in the picture
Immune cells that attract patient own tissue are Th2 , Macrophage And B cell.
In combination they produce the cytokines chemokines and TGF beta on tissue ; all these make chronic inflammations and activate tissue fibroblast and differentiated into myofibroblast as increase production of collagen that make the patient's Skin hardening as fibrosis as thickening over the hand , eosophagous , myocardium, lung, and kidney.
As a results Difficulty swallowing thickening and myocardial infarction. In general we found the Th2, Macrophage and B cell are responsible for this case but we dont kill them because these are patient's immume cells like patient family members we dont kill them. We just treat the symptomps and inflamations with antiinflamatory drugs also some immune suppresive drugs in severe case in where internal organs are affected.
Case is diagnosed clinically mainly by CREST
C= Calcinosis;calcium depositon in the skin.
R= Raynad's phenomena
E= Eosophageal Dysfunction
S= skin thikening and
T=Telangectasia.
ANA always positove in this case.
Written by Me, Student.
From real patient positive findings.
Main etiology of this case:
Chroninc Systemic Autoimmune Disease of unknown origin charaterazied by above symptoms. Noted: Immunity protect our body against pathogens but in this patient , pathogens let the immunity unable to recognize their body connective tissue and producing Auto-antibody that attract our connective tissue instead of pathogens ; suppose to be attracted pathogens. Why do our Antibody attract our own tissue in this case ? No one knows it yet :)
Mechanism of cause: shown in the picture
Immune cells that attract patient own tissue are Th2 , Macrophage And B cell.
In combination they produce the cytokines chemokines and TGF beta on tissue ; all these make chronic inflammations and activate tissue fibroblast and differentiated into myofibroblast as increase production of collagen that make the patient's Skin hardening as fibrosis as thickening over the hand , eosophagous , myocardium, lung, and kidney.
As a results Difficulty swallowing thickening and myocardial infarction. In general we found the Th2, Macrophage and B cell are responsible for this case but we dont kill them because these are patient's immume cells like patient family members we dont kill them. We just treat the symptomps and inflamations with antiinflamatory drugs also some immune suppresive drugs in severe case in where internal organs are affected.
Case is diagnosed clinically mainly by CREST
C= Calcinosis;calcium depositon in the skin.
R= Raynad's phenomena
E= Eosophageal Dysfunction
S= skin thikening and
T=Telangectasia.
ANA always positove in this case.
Written by Me, Student.
From real patient positive findings.
Post a Comment